Article

Multiomics Integration Elucidates Metabolic Modulators of Drug Resistance in Lymphoma

2021-01-08

Abstract excerpt

<h4>Background</h4> Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL). B-cell NHLs rely on Bruton’s tyrosine kinase (BTK) mediated B-cell receptor signaling for survival and disease progression. However, they are often resistant to BTK inhibitors or soon acquire resistance after drug exposure resulting in the drug tolerant form. The drug tolerant clones proliferate faster, have i...

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Literature Corpus work: 6dcf6e2d-49b5-5dce-8a26-3ada459d3755
DOI: 10.1101/2021.01.07.425721

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