Article
PIK3CA mutant tumors depend on oxoglutarate dehydrogenase.
Proceedings of the National Academy of Sciences of the United States of America - 25 Apr 2017
Ilic Nina, Birsoy Kıvanç, Aguirre Andrew J, Kory Nora, Pacold Michael E, Singh Shambhavi, Moody Susan E, DeAngelo Joseph D, Spardy Nicole A, Freinkman Elizaveta, Weir Barbara A, Tsherniak Aviad, Cowley Glenn S, Root David E, Asara John M, Vazquez Francisca, Widlund Hans R, Sabatini David M, Hahn William C
Abstract excerpt
Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function screening in a large number of genomically annotated cancer cell lines. As expected, we found that PIK3CA mutant cancer cells require...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.