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Article

Characterization of Lipid Alterations by Oncogenic PIK3CA Mutations Using Untargeted Lipidomics in Breast Cancer.

Omics : a journal of integrative biology - 1 Jul 2023

Jung Jae Hun, Yang Da-Qing, Song Hongming, Wang Xiangyu, Wu Xinyan, Kim Kwang Pyo, Pandey Akhilesh, Byeon Seul Kee

Abstract excerpt

Lipids play crucial biological roles in health and disease, including in cancers. The phosphatidylinositol 3-kinase (PI3K) signaling pathway is a pivotal promoter of cell growth and proliferation in various types of cancer. The somatic mutations in PIK3CA, the gene coding for the catalytic subunit p110α of PI3K, are frequently present in cancer cells, including breast cancer. Although the most prominent mutants,...

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Identifiers

PMID: 37463468
DOI: 10.1089/omi.2023.0076
PMCID: PMC10366275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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