Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.

British journal of pharmacology - 1 Mar 2012

Bodenmann S, Hohoff C, Freitag C, Deckert J, Rétey J V, Bachmann V, Landolt H-P

Abstract excerpt

BACKGROUND AND PURPOSE: Prolonged wakefulness impairs sustained vigilant attention, measured with the psychomotor vigilance task (PVT), and induces a compensatory increase in sleep intensity in recovery sleep, quantified by slow-wave activity (SWA) in the sleep electroencephalogram (EEG). These effects of sleep deprivation are counteracted by the adenosine receptor antagonist caffeine, implying involvement of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention
Share to Benzhydryl Compounds

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caffeine

Share to Central Nervous System Stimulants

Share to Cross-Over Studies

Share to Receptor, Adenosine A2A

Share to Sleep Deprivation

Share to Wakefulness

Source

Open in PubMed Open full text

Identifiers

PMID: 21950736
DOI: 10.1111/j.1476-5381.2011.01689.x
PMCID: PMC3372839

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation.PMID 21950736Read ↗

A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep.Semantic proximity Read ↗

The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults.Semantic proximity Read ↗

Coffee effectively attenuates impaired attention in ADORA2A C/C-allele carriers during chronic sleep restriction.Semantic proximity Read ↗

Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans.Semantic proximity Read ↗

Functional Polymorphisms in Dopaminergic Genes Modulate Neurobehavioral and Neurophysiological Consequences of Sleep Deprivation.Semantic proximity Read ↗

The association between caffeine consumption and objective sleep variables is dependent on ADORA2A c.1083T>C genotypes.Semantic proximity Read ↗

Effects of the adenosine deaminase polymorphism and caffeine intake on sleep parameters in a large population sample.Semantic proximity Read ↗

The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.Semantic proximity Read ↗

Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism.Semantic proximity Read ↗

Caffeine consumption and behavioral symptoms: influence of ADORA2A and DRD2 genes on inattention.Semantic proximity Read ↗

Genotype-dependent differences in sleep, vigilance, and response to stimulants.Semantic proximity Read ↗

A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.