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Article

Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease on chromosome 7p15.3.

Neurogenetics - 1 Jul 2017

Murthy Megha N, Blauwendraat Cornelis, Guelfi Sebastian, Hardy John, Lewis Patrick A, Trabzuni Daniah

Abstract excerpt

Genome wide association studies (GWAS) for Parkinson's disease (PD) have previously revealed a significant association with a locus on chromosome 7p15.3, initially designated as the glycoprotein non-metastatic melanoma protein B (GPNMB) locus. In this study, the functional consequences of this association on expression were explored in depth by integrating different expression quantitative trait locus (eQTL)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Membrane Glycoproteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 28391543
DOI: 10.1007/s10048-017-0514-8
PMCID: PMC5522530

Genes

GPNMB
KLHL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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