Article
No association of GPNMB rs156429 polymorphism with Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy in Chinese population.
Neuroscience letters - 27 May 2016
Xu YaQian, Chen YongPing, Ou RuWei, Wei Qian-Qian, Cao Bei, Chen Ke, Shang Hui-Fang
Abstract excerpt
BACKGROUND: The rs156429 polymorphism in the glycoprotein nonmetastatic melanoma protein B (GPNMB) gene was found to be associated with the risk for Parkinson disease (PD) in Caucasian population by genome-wide association studies (GWAS). Recently, encoded protein, GPNMB, was identified as a novel neuro-protective factor in amyotrophic lateral sclerosis (ALS). The overlapping of clinical manifestations and...
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