Article
Methods to determine mechanism of action of anti-influenza inhibitors.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
Luttick Angela, Hamilton Stephanie, Tucker Simon P
Abstract excerpt
Mechanism of action studies can be used to demonstrate an inhibitor's ability to specifically inhibit viral replication via a virus-specific or host cell target. A well-characterized mechanism of action is useful in evaluating potential off-target toxicities (e.g., a viral polymerase inhibitor may be assessed for inhibition of host polymerase) and in designing studies to monitor the development of resistance....
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