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Article

Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation.

Antiviral research - 1 Jun 2018

Peng Minhua, Swarbrick Crystall Marie Dawn, Chan Kitti Wing-Ki, Luo Dahai, Zhang Wei, Lai Xiaoping, Li Geng, Vasudevan Subhash G

Abstract excerpt

We previously showed that luteolin, a well-known plant-derived component found in the "heat clearing" class of Traditional Chinese Medicine (TCM) herbs, is an uncompetitive inhibitor (Ki 58.6 μM) of the host proprotein convertase furin, an endoprotease that is required for maturation of flaviviruses in the trans-Golgi compartment. Luteolin also weakly inhibited recombinant dengue virus NS2B/NS3 protease (Ki...

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PMID: 29665375
DOI: 10.1016/j.antiviral.2018.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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