Article
Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.
Molecular cell - 6 Apr 2017
Hu Mengjie, Luo Qiang, Alitongbieke Gulimiran, Chong Shuyi, Xu Chenting, Xie Lei, Chen Xiaohui, Zhang Duo, Zhou Yuqi, Wang Zhaokai, Ye Xiaohong, Cai Lijun, Zhang Fang, Chen Huibin, Jiang Fuquan, Fang Hui, Yang Shanjun, Liu Jie, Diaz-Meco Maria T, Su Ying, Zhou Hu, Moscat Jorge, Lin Xiangzhi, Zhang Xiao-Kun
Abstract excerpt
Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting mitochondria. Here, we report that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit inflammation and induce autophagy in a Nur77-dependent manner. Celastrol promotes Nur77 translocation from the...
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