Article

Fas apoptotic inhibitor molecule 2 mitigates metabolic dysfunction-associated fatty liver disease through autophagic CRTC2 degradation

2025-03-24

Abstract excerpt

<title>Abstract</title> <p>Lysosomal membrane proteins (LMPs) play fundamental roles in the lysosomal degradation of proteins and are attractive drug targets for metabolic dysfunction-associated fatty liver disease (MAFLD). Fas apoptotic inhibitory molecule 2 (FAIM2), an LMP, is previously recognized as an inhibitor of apoptosis in a variety of diseases. Here, we reveal that FAIM2 is an inhibitor of fatty acid sy...

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Literature Corpus work: 61a91920-ebab-53d3-9208-17b72936686f
DOI: 10.21203/rs.3.rs-6110029/v1

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Fas apoptotic inhibitor molecule 2 mitigates metabolic dysfunction-associated fatty liver disease through autophagic CRTC2 degradationDOI 10.21203/rs.3.rs-6110029/v1Read

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