Article
High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology of Lung Cancer Consortium.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 May 2026
Liu Yanhong, Li Yafang, Byun Jinyoung, Shaw Vikram R, Pikielny Claudio, Peng Bo, Cheng Chao, Tsavachidis Spiridon, Xiao Xiangjun, Zhu Dakai, Han Younghun, Gorlov Ivan P, Gorlova Olga Y, Cole Michael, Gaba Colette R, Crawford Erin L, Purrington Kristen, Goode Ellen L, Yang Ping, McKay James, Field John K, Liu Geoffrey, Hung Rayjean J, Xia Jun, Choi Jiyeon, Schabath Matthew B, LoPiccolo Jaclyn, Christiani David C, Bailey-Wilson Joan, Schwartz Ann G, Willey James C, Mandal Diptasri, Pinney Susan M, Amos Christopher I
Abstract excerpt
INTRODUCTION: Rare, deleterious germline variants are key contributors to inherited lung cancer (LC) risk. The Genetic Epidemiology of LC Consortium (GELCC) has curated valuable high-risk LC families and is uniquely positioned to uncover rare, high-penetrance variants underlying familial LC (FLC). METHODS: We performed whole-genome and exome sequencing on germline DNA from 120 high-risk LC families (177 FLC...
Topics
Join the communities discussing this publication.