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Article

Actin cytoskeleton regulator Arp2/3 complex is required for DLL1 activating Notch1 signaling to maintain the stem cell phenotype of glioma initiating cells.

Oncotarget - 16 May 2017

Zhang Chen, Hai Long, Zhu Meng, Yu Shengping, Li Tao, Lin Yu, Liu Bo, Zhou Xingchen, Chen Lei, Zhao Pengfei, Zhou Hua, Huang Yubao, Zhang Kai, Ren Bingcheng, Yang Xuejun

Abstract excerpt

Glioblastoma (GBM) is the most common and lethal primary intracranial tumor. Actin cytoskeleton regulator Arp2/3 complex stimulates glioma cell motility and migration, and thus triggers tumor invasion. However, little is known regarding the role of actin cytoskeleton in maintaining the stem cell phenotype. Here, we showed that Arp2/3 complex improved stem cell phenotype maintenance through sustaining the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28380416
DOI: 10.18632/oncotarget.16495
PMCID: PMC5464873

Genes

DLL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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