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Article

Aberrant Notch signaling in glioblastoma stem cells contributes to tumor recurrence and invasion

10 Jun 2016

Abstract excerpt

Upregulation of the Notch signaling pathway in cancer stem cells and side population (SP) cells has a major role in maintenance, self-renewal and chemoresistance. The present study isolated a cancer stem cell-like SP accounting for 4.1% of a glioblastoma cell population using a Hoechst 33342 dye exclusion assay. In this glioblastoma SP, the expression of of Notch1 signaling proteins Notch1 intracellular domain...

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Identifiers

PMID: 27315154
DOI: 10.3892/mmr.2016.5391

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