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Article

ARPC1B promotes mesenchymal phenotype maintenance and radiotherapy resistance by blocking TRIM21-mediated degradation of IFI16 and HuR in glioma stem cells.

Journal of experimental & clinical cancer research : CR - 16 Nov 2022

Gao Zijie, Xu Jianye, Fan Yang, Zhang Zongpu, Wang Huizhi, Qian Mingyu, Zhang Ping, Deng Lin, Shen Jie, Xue Hao, Zhao Rongrong, Zhou Teng, Guo Xing, Li Gang

Abstract excerpt

BACKGROUND: Intratumoral heterogeneity is the primary challenge in the treatment of glioblastoma (GBM). The presence of glioma stem cells (GSCs) and their conversion between different molecular phenotypes contribute to the complexity of heterogeneity, culminating in preferential resistance to radiotherapy. ARP2/3 (actin-related protein-2/3) complexes (ARPs) are associated with cancer migration, invasion and...

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Identifiers

PMID: 36380368
DOI: 10.1186/s13046-022-02526-8
PMCID: PMC9667586

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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