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The role of the SWI/SNF chromatin remodeling complex in maintaining the stemness of glioma initiating cells

10 Apr 2017

Abstract excerpt

Glioma initiating cells (GICs) are thought to contribute to therapeutic resistance and tumor recurrence in glioblastoma, a lethal primary brain tumor in adults. Although the stem-like properties of GICs, such as self-renewal and tumorigenicity, are epigenetically regulated, the role of a major chromatin remodeling complex in human, the SWI/SNF complex, remains unknown in these cells. We here demonstrate that the...

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PMID: 28420882
DOI: 10.1038/s41598-017-00982-3

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