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Article

Impaired helix 12 dynamics due to proline 892 substitutions in the androgen receptor are associated with complete androgen insensitivity.

Human molecular genetics - 15 Mar 2006

Elhaji Youssef A, Stoica Ileana, Dennis Sheldon, Purisima Enrico O, Lumbroso Rose, Beitel Lenore K, Trifiro Mark A

Abstract excerpt

Structural studies of the ligand-binding domain (LBD) of several steroid receptors have revealed that the dynamic properties of the C-terminal helix 12 (H12) are the major determinant of the activation mode of these receptors. H12 exhibits high mobility and different conformations in the absence of ligand. Upon ligand binding, H12 is stabilized in a precise position to seal the ligand-binding pocket and finalize...

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Identifiers

PMID: 16449235
DOI: 10.1093/hmg/ddl009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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