Article
The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nature chemical biology - 1 Mar 2018
Joedicke Lisa, Mao Jiafei, Kuenze Georg, Reinhart Christoph, Kalavacherla Tejaswi, Jonker Hendrik R A, Richter Christian, Schwalbe Harald, Meiler Jens, Preu Julia, Michel Hartmut, Glaubitz Clemens
Abstract excerpt
G-protein-coupled receptors (GPCRs) are the most important signal transducers in higher eukaryotes. Despite considerable progress, the molecular basis of subtype-specific ligand selectivity, especially for peptide receptors, remains unknown. Here, by integrating DNP-enhanced solid-state NMR spectroscopy with advanced molecular modeling and docking, the mechanism of the subtype selectivity of human bradykinin...
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