Article
Genome-wide association analysis for chronic venous disease identifies EFEMP1 and KCNH8 as susceptibility loci.
Scientific reports - 4 Apr 2017
Ellinghaus Eva, Ellinghaus David, Krusche Petra, Greiner Aljoscha, Schreiber Claudia, Nikolaus Susanna, Gieger Christian, Strauch Konstantin, Lieb Wolfgang, Rosenstiel Philip, Frings Norbert, Fiebig Andreas, Schreiber Stefan, Franke Andre
Abstract excerpt
Chronic venous disease (CVD) is a multifactorial condition representing one of the most common disorders among populations of Western countries. The heritability of about 17% suggests genetic risk factors in CVD etiology. However, so far the genetic causes are unknown. We undertook the hitherto first genome-wide association study (GWAS) for CVD, analyzing more than 1.93 M SNPs in 4,942 German individuals,...
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