Article
Forkhead box C2 promoter variant c.-512C>T is associated with increased susceptibility to chronic venous diseases.
PloS one - 1 Jan 2014
Surendran Sumi, Girijamma Athira, Nair Radhakrishnan, Ramegowda Kalpana S, Nair Divya H, Thulaseedharan Jissa V, Lakkappa Ravikumar B, Kamalapurkar Giridhar, Kartha Chandrasekharan C
Abstract excerpt
Chronic venous disease (CVD) is one of the most prevalent yet underrated disorders worldwide. High heritability estimates of CVD indicate prominent genetic components in its etiology and pathology. Mutations in human forkhead box C2 (FoxC2) gene are strongly associated with valve failure in saphenous and deep veins of lower extremities. We explored the association of genetic variants of FoxC2 as well as FoxC2...
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