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Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.

Scientific reports - 3 Jun 2020

Morimoto Kento, Numata Koki, Daitoku Yoko, Hamada Yuko, Kobayashi Keiko, Kato Kanako, Suzuki Hayate, Ayabe Shinya, Yoshiki Atsushi, Takahashi Satoru, Murata Kazuya, Mizuno Seiya, Sugiyama Fumihiro

Abstract excerpt

F1 hybrid progenies between related subspecies often show hybrid sterility (HS) or inviability. HS is caused by failure of meiotic chromosome synapsis and sex body formation in house mouse. Previous studies identified two HS critical genomic regions named Hstx2 on Chr X and Hst1 on Chr 17 by murine forward genetic approaches. HS gene on Hst1 was reported to be Prdm9. Intersubspecific polymorphisms of Prdm9 induce...

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Share to Histone-Lysine N-Methyltransferase
Share to Hybridization, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred ICR

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Identifiers

PMID: 32493902
DOI: 10.1038/s41598-020-65986-y
PMCID: PMC7270182

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