Article
Cousins not twins: intratumoural and intertumoural heterogeneity in syndromic neuroendocrine tumours.
The Journal of pathology - 1 Jul 2017
Flynn Aidan, Dwight Trisha, Benn Diana, Deb Siddhartha, Colebatch Andrew J, Fox Stephen, Harris Jessica, Duncan Emma L, Robinson Bruce, Hogg Annette, Ellul Jason, To Henry, Duong Cuong, Miller Julie A, Yates Christopher, James Paul, Trainer Alison, Gill Anthony J, Clifton-Bligh Roderick, Hicks Rodney J, Tothill Richard W
Abstract excerpt
Hereditary endocrine neoplasias, including phaeochromocytoma/paraganglioma and medullary thyroid cancer, are caused by autosomal dominant mutations in several familial cancer genes. A common feature of these diseases is the presentation of multiple primary tumours, or multifocal disease representing independent tumour clones that have arisen from the same initiating genetic lesion, but have undergone independent...
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