Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced methods to detect haplotypic effects on gene expression.

Bioinformatics (Oxford, England) - 1 Aug 2017

Brown Robert, Kichaev Gleb, Mancuso Nicholas, Boocock James, Pasaniuc Bogdan

Abstract excerpt

MOTIVATION: Expression quantitative trait loci (eQTLs), genetic variants associated with gene expression levels, are identified in eQTL mapping studies. Such studies typically test for an association between single nucleotide polymorphisms (SNPs) and expression under an additive model, which ignores interaction and haplotypic effects. Mismatches between the model tested and the underlying genetic architecture can...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Share to Statistics as Topic

Source

Open in PubMed Open full text

Identifiers

PMID: 28369161
DOI: 10.1093/bioinformatics/btx142
PMCID: PMC5860109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced methods to detect haplotypic effects on gene expression.PMID 28369161Read ↗

Combinatorial and statistical prediction of gene expression from haplotype sequence.Semantic proximity Read ↗

eQTLHap: a tool for comprehensive eQTL analysis considering haplotypic and genotypic effects.Semantic proximity Read ↗

Accounting for Non-genetic Factors Improves the Power of eQTL StudiesSemantic proximity Read ↗

Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies.Semantic proximity Read ↗

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL data.Semantic proximity Read ↗

Haplotype-aware modeling of cis-regulatory effects highlights the gaps remaining in eQTL dataSemantic proximity Read ↗

Leveraging allele-specific expression to refine fine-mapping for eQTL studiesSemantic proximity Read ↗

Congruence of additive and non-additive effects on gene expression estimated from pedigree and SNP data.Semantic proximity Read ↗

Analysis of the impact of genetic variation on human gene expression.Semantic proximity Read ↗

Understanding mechanisms underlying human gene expression variation with RNA sequencing.Semantic proximity Read ↗

Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.Semantic proximity Read ↗

Genetic Architecture of Gene Expression in European and African Americans: An eQTL Mapping Study in GENOA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.