Article
Understanding mechanisms underlying human gene expression variation with RNA sequencing.
Nature - 1 Apr 2010
Pickrell Joseph K, Marioni John C, Pai Athma A, Degner Jacob F, Engelhardt Barbara E, Nkadori Everlyne, Veyrieras Jean-Baptiste, Stephens Matthew, Gilad Yoav, Pritchard Jonathan K
Abstract excerpt
Understanding the genetic mechanisms underlying natural variation in gene expression is a central goal of both medical and evolutionary genetics, and studies of expression quantitative trait loci (eQTLs) have become an important tool for achieving this goal. Although all eQTL studies so far have assayed messenger RNA levels using expression microarrays, recent advances in RNA sequencing enable the analysis of...
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