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Article

In vivo EPR pharmacokinetic evaluation of the redox status and the blood brain barrier permeability in the SOD1G93A ALS rat model.

Free radical biology & medicine - 1 Jul 2017

Stamenković Stefan, Pavićević Aleksandra, Mojović Miloš, Popović-Bijelić Ana, Selaković Vesna, Andjus Pavle, Bačić Goran

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder affecting the motor pathways of the central nervous system. Although a number of pathophysiological mechanisms have been described in the disease, post mortem and animal model studies indicate blood-brain barrier (BBB) disruption and elevated production of reactive oxygen species as major contributors to disease pathology. In this study,...

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PMID: 28366802
DOI: 10.1016/j.freeradbiomed.2017.03.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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