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Article

Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

The European journal of neuroscience - 1 Mar 2007

Niessen Heiko G, Debska-Vielhaber Grazyna, Sander Kerstin, Angenstein Frank, Ludolph Albert C, Hilfert Liane, Willker Wieland, Leibfritz Dieter, Heinze Hans-Jochen, Kunz Wolfram S, Vielhaber Stefan

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by a progressive loss of motor neurons. Visualizing corresponding metabolic changes in the brain of patients with ALS with proton magnetic resonance spectroscopy ((1)H-MRS) may provide surrogate markers for an early disease detection, for monitoring the progression and for evaluating a treatment response. The primary objective...

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Identifiers

PMID: 17432958
DOI: 10.1111/j.1460-9568.2007.05415.x

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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