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Article

In vivo kinetic approach reveals slow SOD1 turnover in the CNS

14 Jun 2015

Abstract excerpt

Therapeutic strategies that target disease-associated transcripts are being developed for a variety of neurodegenerative syndromes. Protein levels change as a function of their half-life, a property that critically influences the timing and application of therapeutics. In addition, both protein kinetics and concentration may play important roles in neurodegeneration; therefore, it is essential to understand in...

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PMID: 26075819
DOI: 10.1172/jci80705

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