Article
Assessment of oxidative stress in the spontaneously hypertensive rat brain using electron spin resonance (ESR) imaging and in vivo L-Band ESR.
Hypertension research : official journal of the Japanese Society of Hypertension - 1 Jul 2004
Lee Masaichi-Chang-Il, Shoji Hirofumi, Miyazaki Hiroyuki, Yoshino Fumihiko, Hori Norio, Toyoda Minoru, Ikeda Yukio, Anzai Kazunori, Ikota Nobuo, Ozawa Toshihiko
Abstract excerpt
This study examined the blood brain barrier (BBB)-permeable nitroxyl compound, 3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl (MC-PROXYL), as a spin probe for the assessment of oxidative stress in the brain by electron spin resonance (ESR) imaging and in vivo L-band ESR. Preliminary comparisons were made by ESR imaging of MC-PROXYL in the isolated brains of normal Wistar-Kyoto rats (WKY), spontaneously...
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