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Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression

14 Dec 2023

Abstract excerpt

Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial cancer formation and progression, but what molecules and how they trigger EMT is largely unknown. Here we performed spatial transcriptomic and functional analyses on samples of multistage esophageal squamous-cell carcinoma (ESCC) from mice and humans to decipher these critical issues. By investigating spatiotemporal gene...

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PMID: 38097539
DOI: 10.1038/s41392-023-01710-2

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