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Full-Genome Hepatitis B Virus Genotyping: A Juxtaposition of Next-Generation and Clone-Based Sequencing Approaches-Comparing Genotyping Methods of Hepatitis B Virus.

Viruses - 15 Jan 2026

Hu Li-Ping, Chen Qin-Yan, Huang Mei-Lin, Zhang Wen-Jia, Huang Xiao-Qian, Yi Xian-Feng, Jia Hui-Hua

Abstract excerpt

Background: The enhanced sensitivity of next-generation sequencing (NGS) for assessing hepatitis B virus (HBV) quasispecies heterogeneity over clone-based sequencing (CBS) is well documented. However, its comparative reliability for genotype determination remains an open question. Objective: This study aimed to directly compare the performance of NGS and CBS for genotyping HBV using the entire viral genome....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 41600874
DOI: 10.3390/v18010112
PMCID: PMC12846481

Genes

CBS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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