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Article

Alteration of the α1β2/α2β1 subunit interface contributes to the increased hemoglobin-oxygen affinity of high-altitude deer mice.

PloS one - 1 Jan 2017

Inoguchi Noriko, Mizuno Nobuhiro, Baba Seiki, Kumasaka Takashi, Natarajan Chandrasekhar, Storz Jay F, Moriyama Hideaki

Abstract excerpt

BACKGROUND: Deer mice (Peromyscus maniculatus) that are native to high altitudes in the Rocky Mountains have evolved hemoglobins with an increased oxygen-binding affinity relative to those of lowland conspecifics. To elucidate the molecular mechanisms responsible for the evolved increase in hemoglobin-oxygen affinity, the crystal structure of the highland hemoglobin variant was solved and compared with the...

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Identifiers

PMID: 28362841
DOI: 10.1371/journal.pone.0174921
PMCID: PMC5376325

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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