Article
High-altitude ancestry and hypoxia acclimation have distinct effects on exercise capacity and muscle phenotype in deer mice.
American journal of physiology. Regulatory, integrative and comparative physiology - 1 May 2015
Lui Mikaela A, Mahalingam Sajeni, Patel Paras, Connaty Alex D, Ivy Catherine M, Cheviron Zachary A, Storz Jay F, McClelland Grant B, Scott Graham R
Abstract excerpt
The hypoxic and cold environment at high altitudes requires that small mammals sustain high rates of O2 transport for exercise and thermogenesis while facing a diminished O2 availability. We used laboratory-born and -raised deer mice (Peromyscus maniculatus) from highland and lowland populations to determine the interactive effects of ancestry and hypoxia acclimation on exercise performance. Maximal O₂consumption...
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