Article
Mutant hemoglobins (alpha 119-Ala and beta 55-Ser): functions related to high-altitude respiration in geese.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 1993
Weber R E, Jessen T H, Malte H, Tame J
Abstract excerpt
The unusually high blood-O2 affinity in the bar-headed and Andean geese is a necessary adaptation for migration across high mountain ranges. The amino acid residues alpha-119 and beta-55, which form an alpha 1 beta 1 contact in human hemoglobin (Hb), are altered in bar-headed and Andean geese, respectively, which suggests that loss of this contact increases O2 affinity. Two mutant human Hbs with equivalent...
Topics
- 2,3-Diphosphoglycerate
- Adult
- Altitude
- Animals
- Diphosphoglyceric Acids
- Geese
- Gene Amplification
- Hemoglobin A
- Hemoglobins, Abnormal
- Humans
- Hydrogen-Ion Concentration