Article
Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity.
The Journal of biological chemistry - 14 Feb 2003
Shirasawa Takuji, Izumizaki Masahiko, Suzuki Yo-ichi, Ishihara Akihiko, Shimizu Takahiko, Tamaki Masakatsu, Huang Fei, Koizumi Ken-ichi, Iwase Michiko, Sakai Hiromi, Tsuchida Eishun, Ueshima Kenji, Inoue Hiroshi, Koseki Haruhiko, Senda Toshiya, Kuriyama Takayuki, Homma Ikuo
Abstract excerpt
The oxygen affinity of hemoglobin is critical for gas exchange in the lung and O(2) delivery in peripheral tissues. In the present study, we generated model mice that carry low affinity hemoglobin with the Titusville mutation in the alpha-globin gene or Presbyterian mutation in the beta-globin gene. The mutant mice showed increased O(2) consumption and CO(2) production in tissue metabolism, suggesting enhanced...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.