The evolutionary footprint of histidine in hemoglobin and myoglobin: an implication towards their function.

Abstract excerpt

Hemoglobin and myoglobin are essential oxygen-binding proteins whose structural integrity is critical for proper function. This study performs atomic-level comparisons of wild-type and mutant forms to investigate how specific mutations impact oxygen-binding affinity. Substitution of the proximal histidine, responsible for coordinating the iron atom in the heme group, with tyrosine results shortening of bond...

Topics

• Myoglobin
• Histidine
• Animals
• Hemoglobins
• Evolution, Molecular
• Models, Molecular
• Oxygen
• Mutation
• Humans