Article
Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole.
BMC evolutionary biology - 16 Jul 2010
Campbell Kevin L, Storz Jay F, Signore Anthony V, Moriyama Hideaki, Catania Kenneth C, Payson Alexander P, Bonaventura Joseph, Stetefeld Jörg, Weber Roy E
Abstract excerpt
BACKGROUND: Elevated blood O(2) affinity enhances survival at low O(2) pressures, and is perhaps the best known and most broadly accepted evolutionary adjustment of terrestrial vertebrates to environmental hypoxia. This phenotype arises by increasing the intrinsic O(2) affinity of the hemoglobin (Hb) molecule, by decreasing the intracellular concentration of allosteric effectors (e.g., 2,3-diphosphoglycerate;...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.