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Article

Evolutionary and functional insights into the mechanism underlying high-altitude adaptation of deer mouse hemoglobin.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Storz Jay F, Runck Amy M, Sabatino Stephen J, Kelly John K, Ferrand Nuno, Moriyama Hideaki, Weber Roy E, Fago Angela

Abstract excerpt

Adaptive modifications of heteromeric proteins may involve genetically based changes in single subunit polypeptides or parallel changes in multiple genes that encode distinct, interacting subunits. Here we investigate these possibilities by conducting a combined evolutionary and functional analysis of duplicated globin genes in natural populations of deer mice (Peromyscus maniculatus) that are adapted to...

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Identifiers

PMID: 19667207
DOI: 10.1073/pnas.0905224106
PMCID: PMC2732835

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