Article
Intraspecific polymorphism, interspecific divergence, and the origins of function-altering mutations in deer mouse hemoglobin.
Molecular biology and evolution - 1 Apr 2015
Natarajan Chandrasekhar, Hoffmann Federico G, Lanier Hayley C, Wolf Cole J, Cheviron Zachary A, Spangler Matthew L, Weber Roy E, Fago Angela, Storz Jay F
Abstract excerpt
Major challenges for illuminating the genetic basis of phenotypic evolution are to identify causative mutations, to quantify their functional effects, to trace their origins as new or preexisting variants, and to assess the manner in which segregating variation is transduced into species differences. Here, we report an experimental analysis of genetic variation in hemoglobin (Hb) function within and among species...
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