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Article

Genetic variation in haemoglobin is associated with evolved changes in breathing in high-altitude deer mice.

The Journal of experimental biology - 15 Jan 2022

Ivy Catherine M, Wearing Oliver H, Natarajan Chandrasekhar, Schweizer Rena M, Gutiérrez-Pinto Natalia, Velotta Jonathan P, Campbell-Staton Shane C, Petersen Elin E, Fago Angela, Cheviron Zachary A, Storz Jay F, Scott Graham R

Abstract excerpt

Physiological systems often have emergent properties but the effects of genetic variation on physiology are often unknown, which presents a major challenge to understanding the mechanisms of phenotypic evolution. We investigated whether genetic variants in haemoglobin (Hb) that contribute to high-altitude adaptation in deer mice (Peromyscus maniculatus) are associated with evolved changes in the control of...

Topics

Altitude
Animals
Genetic Variation
Hemoglobins
Hypoxia
Mice
Oxygen
Peromyscus
Respiration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34913467
DOI: 10.1242/jeb.243595
PMCID: PMC8917448

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