Epithelial fibroblast triggering and interactions in pulmonary fibrosis

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is characterised by repeated injury to the alveolar epithelium with loss of lung epithelial cells and abnormal tissue repair, resulting in excessive accumulation of fibroblasts and myofibroblasts, deposition of extracellular matrix components and distortion of lung architecture, eventually leading to respiratory failure. There is growing circumstantial evidence to suggest that i...

Topics

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• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Neonatal Respiratory Health Research
• Occupational and environmental lung diseases

Identifiers and source

Literature Corpus work

2a2c21fc-7a75-5a95-ae2b-0f033d2de000

DOI

10.1183/09059180.00010904