Article
Report of novel H105R, D29N, V27A mutations in the methyltransferase region of the HEV genome in patients with acute liver failure.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Jun 2017
Borkakoti Jayanta, Ahmed Giasuddin, Rai Arvind, Kar Premashis
Abstract excerpt
BACKGROUND: The Hepatitis E virus (HEV) has been responsible for major outbreaks in the developing countries affecting millions of people and acute sporadic hepatitis worldwide. The HEV methyltransferase is important for capping the 5'-end of the viral pregenomic RNA which is critical for viral infection. OBJECTIVES: We aimed to assess the substitutional profile in the HEV methyltransferase region in patients...
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