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Article

Genetic determinants of host- and virus-derived insertions for hepatitis E virus replication

6 Jun 2024

Abstract excerpt

Hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of acute viral hepatitis in humans. Recent data suggest that HEV has a very heterogeneous hypervariable region (HVR), which can tolerate major genomic rearrangements. In this study, we identify insertions of previously undescribed sequence snippets in serum samples of a ribavirin treatment failure patient. These insertions...

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PMID: 38844458
DOI: 10.1038/s41467-024-49219-8

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