Article
The hepatitis E virus nonstructural polyprotein.
Future microbiology - 1 Aug 2017
Parvez Mohammad Khalid
Abstract excerpt
Hepatitis E virus (HEV) is a globally important pathogen of acute and chronic hepatitis in humans. The HEV ORF1 gene encodes a nonstructural polyprotein, essential for RNA replication and virus infectivity. Expression and processing of ORF1 polyprotein are shown in prokaryotic and eukaryotic systems, however, its proteolysis into individual proteins is still debated. While molecular or biochemical...
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