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Article

The hepatitis E virus polyproline region is involved in viral adaptation.

PloS one - 1 Jan 2012

Purdy Michael A, Lara James, Khudyakov Yury E

Abstract excerpt

Genomes of hepatitis E virus (HEV), rubivirus and cutthroat virus (CTV) contain a region of high proline density and low amino acid (aa) complexity, named the polyproline region (PPR). In HEV genotypes 1, 3 and 4, it is the only region within the non-structural open reading frame (ORF1) with positive selection (4-10 codons with dN/dS>1). This region has the highest density of sites with homoplasy values >0.5....

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Identifiers

PMID: 22545153
DOI: 10.1371/journal.pone.0035974
PMCID: PMC3335810

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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