Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity.

World journal of gastroenterology - 28 Jan 2017

Parvez Mohammad Khalid

Abstract excerpt

AIM: To investigate the role of non-structural open reading frame 1 "Y-domain" sequences in the hepatitis E virus (HEV) life cycle. METHODS: Sequences of human HEV Y-domain (amino acid sequences 216-442) and closely-related viruses were analyzed in silico. Site-directed mutagenesis of the Y-domain (HEV SAR55) was carried out and studied in the replicon-baculovirus-hepatoma cell model. In vitro transcribed mRNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Green Fluorescent Proteins
Share to Hep G2 Cells
Share to Hepatitis E virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Open Reading Frames

Share to Protein Domains

Share to Replicon

Share to Viral Proteins

Share to Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 28216965
DOI: 10.3748/wjg.v23.i4.590
PMCID: PMC5292332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of hepatitis E virus ORF1 "Y-domain": Effects on RNA replication and virion infectivity.PMID 28216965Read ↗

Hepatitis E Virus Mutations: Functional and Clinical Relevance.Semantic proximity Read ↗

Hepatitis E Virus ReplicationSemantic proximity Read ↗

Identification of functional cis-acting RNA elements in the hepatitis E virus genome required for viral replication.Semantic proximity Read ↗

The hepatitis E virus nonstructural polyprotein.Semantic proximity Read ↗

Molecular biology and pathogenesis of hepatitis E virusSemantic proximity Read ↗

Molecular biology and replication of hepatitis E virusSemantic proximity Read ↗

Multifunctional ORF3 protein of hepatitis E virusSemantic proximity Read ↗

Open Reading Frame 4 Is Not Essential in the Replication and Infection of Genotype 1 Hepatitis E Virus.Semantic proximity Read ↗

Genetic determinants of host- and virus-derived insertions for hepatitis E virus replicationSemantic proximity Read ↗

Structural features stabilized by divalent cation coordination within hepatitis E virus ORF1 are critical for viral replicationSemantic proximity Read ↗

An Arginine-Rich Motif in the ORF2 capsid protein regulates the hepatitis E virus lifecycle and interactions with the host cellSemantic proximity Read ↗

Identification of the Intragenomic Promoter Controlling Hepatitis E Virus Subgenomic RNA TranscriptionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.