Article
Genotoxicity testing of sodium formononetin-3'-sulphonate (Sul-F) by assessing bacterial reverse mutation, chromosomal aberrations and micronucleus tests.
Regulatory toxicology and pharmacology : RTP - 1 Jun 2017
Li Chunmei, Gao Yonglin, Wang Yunzhi, Li Guisheng, Fan Xiaochen, Li Yanshen, Guo Chenghua, Tao Jun
Abstract excerpt
As part of a safety evaluation, we evaluated the potential genotoxicity of sodium formononetin-3'-sulphonate (Sul-F) using bacterial reverse mutation assay, chromosomal aberrations detection, and mouse micronucleus test. In bacterial reverse mutation assay using five strains of Salmonella typhimurium (TA97, TA98, TA100, TA102 and TA1535), Sul-F (250, 500, 1000, 2000, 4000 μg/plate) did not increase the number of...
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