Article
Cytotoxic and genotoxic properties of tert.-butyl-p-quinone (TBQ) in an in vitro assay system with Chinese hamster V79 cells and in strain D7 of Saccharomyces cerevisiae.
Mutation research - 1 Mar 1993
Rogers C G, Boyes B G, Matula T I, Neville G, Stapley R
Abstract excerpt
tert.-Butyl-p-quinone (TBQ), a major metabolite of the phenolic antioxidant tert.-butyl-4-hydroxyanisole (BHA), was examined for cytotoxic and genotoxic properties in an in vitro assay system with Chinese hamster V79 cells and in diploid strain D7 of Saccharomyces cerevisiae. TBQ was prepared from BHA by oxidative demethylation with sodium nitrite at low pH. Spectroscopic analyses identified the crystalline...
Topics
- Analysis of Variance
- Animals
- Benzoquinones
- Cell Division
- Cell Line
- Cell Survival
- Cricetinae
- Cricetulus
- Drug Resistance
- Gene Conversion
- Liver