Article
The anticlastogenicity of beta-carotene evaluated on human hepatoma cells.
Mutation research - 1 Dec 1993
Salvadori D M, Ribeiro L R, Natarajan A T
Abstract excerpt
The efficiency of beta-carotene as a modulatory agent against clastogenicity induced by cyclophosphamide (CPA), an indirect-acting mutagen, and mitomycin C (MMC), a direct-acting mutagen, was evaluated in human hepatoma cells (Hep G2) using three different treatment regimes. Six doses of beta-carotene, 0.25, 0.5, 1.0, 2.0, 4.0 and 6.0 microM, were tested as pre-treatment, simultaneous treatment and pre- +...
Topics
- Carcinoma, Hepatocellular
- Carotenoids
- Cyclophosphamide
- Humans
- Micronucleus Tests
- Mitomycin
- Mutation
- Tumor Cells, Cultured
- beta Carotene