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A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

1 Mar 2017

Abstract excerpt

During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmental function is seen in human glioma, wherein Olig2 is required for maintenance of stem-like cells that drive tumor growth. The mitogenic/gliomagenic functions of Olig2...

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PMID: 28355568
DOI: 10.1016/j.celrep.2017.03.003

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