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Article

PDGF-R inhibition induces glioblastoma cell differentiation via DUSP1/p38MAPK signalling

7 Apr 2022

Abstract excerpt

Abstract Glioblastoma (GBM) is the most common and fatal primary brain tumour in adults. Considering that resistance to current therapies leads to limited response in patients, new therapeutic options are urgently needed. In recent years, differentiation therapy has been proposed as an alternative for GBM treatment, with the aim of bringing cancer cells into a post-mitotic/differentiated state, ultimately...

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PMID: 35393545
DOI: 10.1038/s41388-022-02294-x

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