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Article

Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis.

Development (Cambridge, England) - 1 Oct 2011

Ali Fahad, Hindley Chris, McDowell Gary, Deibler Richard, Jones Alison, Kirschner Marc, Guillemot Francois, Philpott Anna

Abstract excerpt

During development of the central nervous system, the transition from progenitor maintenance to differentiation is directly triggered by a lengthening of the cell cycle that occurs as development progresses. However, the mechanistic basis of this regulation is unknown. The proneural transcription factor Neurogenin 2 (Ngn2) acts as a master regulator of neuronal differentiation. Here, we demonstrate that Ngn2 is...

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Identifiers

PMID: 21852393
DOI: 10.1242/dev.067900
PMCID: PMC3171226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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